AFFECTİVE AND PSYCHOTİC PROCESS TRİGGERED BY METHYLPHENİDATE
Keywords:
Methylphenidate, mania, depression, psychosisAbstract
Methylphenidate is used in treating patient with attention deficit hyperactivity disorder in adults and children (ADHD), narcolepsy, depression augmentation treatment, cancer pains. It is known that methylphenidate can cause manic and psychotic symptoms at high doses, even in small groups, at therapeutic doses. In this case report we present two patients, who had no previous psychiatric outpatient clinic application or psychiatric treatment history, with psychotic manic episode and psychotic depressive episode accompanied by catatonia due to the application of methylphenidateafterthediagnosisofADHD.
References
Gray JD, Punsoni M, Tabori NE, et al. Methylphenidate administration to juvenile rats alters brain areas involved in cognition, motivated behaviors, appetite, and stress. J Neurosci 2007; 27: 7196–7207.
Rappley MD. Attention deficit-hyperactivity disorder. N Engl J Med 2005; 352:165–173
Challman TD, Lipsky JJ. Methylphenidate: it’s pharmacology and uses. Mayo Clin Proc 2000; 75:711-721
Snyder SH. Amphetamine psychosis: a “model” schizophrenia mediated by catecholamines. Am J Psychiatry 1973; 130:61–67
Bell DS. The experimental reproduction of amphetamine psychosis. Arch Gen Psychiatry 1973; 29:35–40
Salvadore G, Quiroz JA, Machado-Vieira R, et al. The neurobiology of the switch process in bipolar disorder: a review. J Clin Psychiatry 2010; 71:1488–501.
Abrial E, Etievant A, Bétry C, et al. Protein kinase C regulates mood-related behaviors and adult hippocampal cell proliferation in rats. Int J Neuropsychopharmacol 2015; 18: pyu031
Meltzer HY, Stahl SM. The dopamine hypothesis of schizophrenia: a review. Schizophr Bull 1976; 2:19–76
Klein-Schwartz W. Pediatric methylphenidate exposures: 7-year experience of poison centers in the United States. Clin Pediatr (Phila) 2003; 42:159-64.
Klampfl K, Quattländer A, Burger R, et al. Case report: intoxication with high dose of long-acting methylphenidate (Con- certa(®)) in a suicidal 14-year-old girl. At-ten Defic Hyperact Disord 2010; 2:221-4.
Fachinformation Concerta 18 mg/36 mg/54 mg Retardtabletten Rote Liste Service Gm-bHFachinfo-Service Janssen-Cilag 2009.
Ross RG. Psychotic and manic-like symptoms during stimulant treatment of attention deficit hyperactivity disorder. Am J Psychiatry 2006; 163:1149Y1152.
McIntyre, RS, Kennedy, SH, Soczynska JK, et al. Attention-deficit/hyperactivity disorder in adults with bipolar disorder. Prim Care Companion J Clin Psychiatry 2010; 12.3.
Frangos E, Athanessenas G, Tsitourides S. Seasonality of the episodes of recurrent affective psychoses: possible prophylactic interventions. J Affect Disord 1980; 2: 239-47
Orr K, Taylor D. Psychostimulants in the treatment of depression: a review of the evidence. CNS Drugs 2007; 21: 239-257.
Adler L, Spencer T, Stein MA, et al. Best
practices in adult ADHD: epidemiology, impairments and differential diagnosis. CNS Spectr 2008; 13.10 Suppl 15: 4.
Wiener J, Kennedy S. Akinesia and mutism following a methylphenidate challenge test, J Clin Psychopharmacol 1985; 5: 231-233.
Barrett SP, Darredeau C, Bordy LE, et al. Characteristics of methylphenidate misuse in a university student sample. Can J Psychiatry 2005; 50:457Y461.
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