Genetics of dependence

Authors

  • Ercan Abay Trakya Üniversitesi Tıp Fakültesi Psikiyatri AD , Trakya Üniversitesi Tıp Fakültesi Psikiyatri AD
  • İbrahim Ateş Trakya Üniversitesi Tıp Fakültesi Psikiyatri AD , Trakya Üniversitesi Tıp Fakültesi Psikiyatri AD

Keywords:

Alcohol dependence, sociodemographic variables, clinical characteristics, gender, treatment outcomes

Abstract

As a result of new findings on the area of molecular genetics, there is growing interest on the genetic aspects of psychiatric disorders. Genetic aspects of dependence of alcohol, tobacco and other psychoactive substances have recently been studied and important information about the candidate genes is obtained. In this review, dopaminergic system which plays an important role on dependence behavior ; human and animal studies on the genetics of dependence and "reward deficiency syndrome" is mentioned.

References

Noble EP; Polymorphisms of the D2 Dopamine Receptor Gene in Alcoholism, Cocaine and Nicotine Dependence and Obesity. Handbook of Psychiatric Genetics, 1997,331351.

Prescott C, Aggen S, Kendler K; Sex-spesific Genetic Influences on the comorbidity of alcoholism and major depression in a population-based sample of US twins. Arch Gen Psychiatry, 2000, 57:803-811.

Pickar D, Rubinow K; Pharmaco-genomics of psychiatric disorders. Trends in Pharmacological Sciences, 2001,22: 75-83.

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Published

2001-05-01

Issue

Vol. 2 No. 2 (2001)

Section

Review

License

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