The Relationship Between Liver Function Tests And Sociodemographic- Clinical Characteristics Of Alcohol Dependent Patients
Keywords:
alcohol dependence, sociodemographic characteristics, liver function testsAbstract
Objective: There are some biochemical factors that are commonly used as screening tests for alcohol use disorders. The well-known liver function tests including SGOT-(AST), SGPT- (ALT), GGT were widely studied in clinical use. In this study, the relationship between liver function tests and sociodemographic-clinical characteristics of alcohol dependent patients were evaluated.
Method: In this study, 312 patients were diagnosed as alcohol dependent according to DSM-IV criteria. All patients were treated as inpatient during the year 1998. The sociodemographic and clinical characteristics of patients were examined by a detailed data sheet. Blood samples were collected in the morning and concealed at optimal conditions. Measures were done at the same calibration value in designated interval all at once. The relationship between sociodemographic-clinical characteristics and laboratory results were evaluated by SPSS statistics programme.
Results: Twenty-seven female (8,7 %) and 285 male (91,3 %) patients were included in this study. The mean age of the sample was 41,0 years (sd = 9,0) and the mean age of initiation for alcohol use was 19,5 years (sd = 5,3). The results of statistical evaluation were determined as follows: There are significant differences among GGT levels according to gender, starting age to drink and withdrawal symptoms.
Conclusion: The duration and level of alcohol consumption determine the liver function test abnormalities. The role and importance of biological markers in alcohol dependence should be studied by detailed prospective-controlled studies.
References
Reynaud M., Schellenberg F., Loise-qux-Meunier M-N, Schwan R., Mara-deix B., Planche R, Gillet C.: Objective Diagnosis of Alcohol Abuse: Compared Values of Carbohydrate-Deficient Transferrin (CDT), [gamma]-Glu-tamyl Transferase (GGT), and Mean Corpuscular Volume (MCV). Alcohol Clin Exp Res, Vol 24, No 9, 2000, 1414-1419.
Bradley K. A.: The primary care practitioner's role in the prevention and management of alcohol problems. Alcohol Health and Research World, 1992: 18(2) 97-104.
Schuckit M.A.: Biological, psycho-gical, and environmental predictors of the alcoholism risk: A longitudinal study. J Stud Alcohol 59:485, 1998.
Schuckit M.A.: Alcohol-Related Disorders. Kaplan And Sadock's Comprehensive Textbook of Psychiatry, seventh edition, Benjamin J Sadock, Virginia Sadock (eds), Lippincott Williams adn Wilkins/ 2000 pp 953-971.
Knott D. H.: Alcohol Problems: Diagnosis and Treatment. New York, Pergamon Press, 1986.
Goodwin D. W: Alcoholism. Kaplan HI, Sadock BJ (eds). Comprehensive Textbook of Psychiatry/V, Williams & Wilkins, 1989.
Goodwin D. W:Alcoholism: The Facts. Second edition, Oxford University Press, New York, 1994.
Ludwig A. M.: Undestanding the Alcoholic's Mind: The nature of craving and how to control it. Oxford University Press, Inc. New York, 1988.
Kaplan H. L, Sadock B. S., Grebb S.A.: Alcohol-related disorders, In Kaplan and Sadocks, Synopsis of Psychiatry, behavioral sciences clinical psychiatry. 7 th Edition, Williams and Wilkins, 1994, pp 396-411.
Paton A. (ed):ABC of Alcohol. BMJ Third edition, London, 1994.
Kalyoncu A., Mırsal H., Pektaş Ö., Şatır T., Serez M., Beyazyürek M.: Yatarak Tedavi Gören Alkol Bağımlıları İçin Örnek Bir Tedavi Programı. Bağımlılık Dergisi Cilt: 1 Sayı: 1 Mart 2000.
Burtis C. A., Ashwood ER.:Tietz Texbook of Clinical Chemistry, 1994, 849.
Bergmeyer H.U., Scheibe P., Wahlefeld A.W.: "Optimization of methods for aspartate aminotransferase and alanine aminotransferase" Clinical Chemistry 1978; l(24):58-73.
Wroblewski E, LaDue J. S.: Proc. Soc.Exp. Biol. Med. 1956; 91:569-571.
Chick J., Kreitman N., Plant M.: Mean cell volume and gamma-glu-tamyl-transpeptidase as markers of drinking in working men. Lancet 12491251, 1981.
Rosman A.S., Lieber C. S.:Biochemical markers of alcohol consumption. Alcohol Health and Research World 1990, 14(3):208-218.
Kalyoncu A., Pektaş Ö., Mırsal H., Şatır T, Pektaş A., Mırsal N., Yılmaz S., Beyazyürek M.:Alkol bağımlılığında alkol kullanım özellikleri ile klinik durum arasındaki ilişkilerin araştırılması. 35th Ulusal Psikiyatri Kongresi, 6-12 Eylül 1999 Trabzon.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Journal of Dependence
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
...