Intranasal abuse of methylphenidate and bupropion: a case report
Keywords:
Methylfenidate, intranasal, abuse, bupropionAbstract
Methylphenidate is a central nervous system stimulant drug that is used for treatment of Attention Deficit Hyperactivity Disorder (ADHD) and bupropion is used for smoking cessation therapy as well as depression treatment. Oral abuse has been reported as a common rout for addiction/ dependency and it is the most reported form of abuse in the literature. In this case, we are going to report the intranasal abuse of methylphenidate and bupropion. Furthermore, off-label use of ethylphenidate, follow-up and its treatment would be explained/ reported.
References
Volkow ND, Fowler JS, Gatley JS, et al. Comparable changes in synaptic dopamine induced by methylphenidate and cocaine in the baboon brain. Synapse 1999; 31: 59-66.
Kolins SH, MacDonald EK, Rush CR. Assessing the abuse potential of methylphenidate in nonhuman and human subjects. Pharmacol Biochem Behav 2001; 68: 611-627.
Luna GC. Use anda buse of amphetamine-type stimulants in the United States of America. Pan Am J Public Health 2001; 9: 114.
Uzbay İT, Yüksel N. Madde kötüye kullanımı ve bağımlılığı. Psikofarmakoloji. N. Yüksel (Ed.). Yenilenmiş 2. Baskı, Ankara: Çizgi Tıp Kitabevi, 2003: 485-520.
Dunner DL, Zisook S, and Billow AA, et al. A prospective safety surveillance study for bupropion sustained-release in the treatment of depression. J Clin Psychiatry 1998; 59: 366–373.
Kim D, Steinhart B. Seizures induced by recreational abuse of bupropion tablets via nasal insufflation. CJEM 2010; 12(2): 158-61.
Graff CL, Pollack GM. Nasal drug administration: potential for targeted central nervous system delivery. J Pharm Sci 2005; 94: 1187-95.
Jaffe SL. Intranasal abuse of prescribed methylphenidate by an alcohol and drug abusing adolescent with ADHD. J Am Acad Child Adolesc Psychiatry 1991; 30: 773-775.
Massello W, Carpenter DA. A fatality due to the intranasal abuse of methylphenidate (Ritalin). J Forensic Sci 1999; 44: 220-221.
What is Ethylphenidate or EPH? Available from: http://www.plantfoodpalace.com/ethylphenidate.html
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Journal of Dependence

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Journal and content of this website is licensed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License. This is in accordance with the Budapest Open Access Initiative (BOAI) definition of open access. The Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) allows users to copy, distribute and transmit unmodified article, and make noncommercial use of the article. The CC BY license permits non-commercial re-use of an open access article, as long as the author is properly attributed.